The Salas y Gómez and Nazca ridges are two seamount chains that stretch across 2,900 kilometers (1,800 miles) in the southeastern Pacific. This region is isolated by the Humboldt Current and the Atacama Trench, producing unique biodiversity with one of the highest levels of marine endemism on Earth. The ridges provide important habitats and migration corridors for many ecologically important species, including 82 threatened or endangered species. Recent explorations have documented the deepest light-dependent reefs on Earth, as well as numerous species new to science. Not only is this region a biodiversity hotspot, it is also culturally significant as Indigenous Pacific Islanders and others have recognized its importance for centuries. Commercial activity is still low in this region. We must act now to protect its unique resources before they are lost forever.